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pentobarbital decreases amounts of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers enhance price of toremifene metabolism, lowering the steady-point out focus in serum.pentobarbital will lessen the extent or influence of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. A